Cross-sectional and longitudinal associations between depressive symptoms and cognitive performance in mild cognitive impairment
Within-person variations in depressive symptom severity are associated with acute cognitive performance differences. Cognitive scores derived during active depressive periods may underestimate longer-term cognitive capabilities. Treating depressive symptoms in MCI may clarify underlying cognitive performance capacity, and help maintain optimal cognitive function for longer.
Authors
- Rory Durcan (ORCID: https://orcid.org/0000-0002-8897-8737)
- John T. O’Brien (ORCID: https://orcid.org/0000-0002-0837-5080)
- Louise Allan (ORCID: https://orcid.org/0000-0002-8912-4901)
- Michael John Firbank (ORCID: https://orcid.org/0000-0002-9536-0185)
- Alan Thomas (ORCID: https://orcid.org/0000-0002-6667-9533)
- Gemma Roberts (ORCID: https://orcid.org/0000-0002-6445-4023)
- Joanna Ciafone (ORCID: https://orcid.org/0000-0003-4339-2510)
- Calum A. Hamilton (ORCID: https://orcid.org/0000-0002-9812-3150)
- Paul C. Donaghy (ORCID: https://orcid.org/0000-0001-7195-4846)
- John‐Paul Taylor (ORCID: https://orcid.org/0000-0001-7958-6558)
Institutions
- University of Exeter (GB)
- University of Cambridge (GB)
- Royal London Hospital (GB)
- University College London (GB)
- Newcastle University (GB)
Publication Details
- Journal
- The British Journal of Psychiatry
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1192/bjp.2025.10341
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Medical Research Council
- NIHR Newcastle Biomedical Research Centre