Low fT3/fT4 ratio as a proxy for muscle wasting in patients with advanced non-small cell lung cancer treated with pembrolizumab
Despite the limited sample size, fT3/fT4 ratio appears to be a promising and accessible biomarker for identifying muscle wasting, which may be linked to diminished treatment response and shorter survival in patients with NSCLC.
Authors
- Ilaria Trestini (ORCID: https://orcid.org/0000-0002-4958-9771)
- Sara Pilotto (ORCID: https://orcid.org/0000-0003-2229-4874)
- Alessandra Dodi (ORCID: https://orcid.org/0000-0002-4029-2170)
- Michèle Milella (ORCID: https://orcid.org/0000-0002-3826-5237)
- Emilio Bria (ORCID: https://orcid.org/0000-0002-2333-704X)
- Ilaria Mariangela Scaglione
- Fotios Loupakis (ORCID: https://orcid.org/0000-0001-9651-0395)
- Maria Cristina Mele (ORCID: https://orcid.org/0000-0002-8463-7062)
- Luca Pasqualin
- Marco Cintoni (ORCID: https://orcid.org/0000-0002-9610-0748)
- Isabella Sperduti (ORCID: https://orcid.org/0000-0001-5115-3099)
- Lorenzo Belluomini (ORCID: https://orcid.org/0000-0003-1981-5499)
- Daniela Tregnago
- Alice Avancini (ORCID: https://orcid.org/0000-0003-2439-4799)
- Marco Sposito (ORCID: https://orcid.org/0009-0004-6749-3214)
- Jessica Insolda
- Serena Eccher
- Alessio Stefani (ORCID: https://orcid.org/0000-0002-5816-4484)
- Marcello Tiseo
- Linda Confortini
Institutions
- University of Verona (IT)
- University of Parma (IT)
- Agostino Gemelli University Polyclinic (IT)
- Azienda Sanitaria Locale Viterbo (IT)
- University Hospitals Parma Medical Center (US)
- National Cancer Institute (MY)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-27
- DOI
- https://doi.org/10.3389/fonc.2025.1635321
- Citations
- 2
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Sanofi
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro
- Università Cattolica del Sacro Cuore
- Daiichi Sankyo Europe