The effect of lesion filling on brain age estimation in multiple sclerosis
Lesion filling modestly improves structural interpretability of brain age estimates in MS but has limited effect on clinical correlations. The high concordance between lesion-filled and non-lesion-filled estimates confirms the robustness of brain age as a biomarker, while supporting the use of lesion correction when structural precision is essential.
Authors
- Salem Hannoun (ORCID: https://orcid.org/0000-0002-5982-3242)
- Samia Joseph Khoury (ORCID: https://orcid.org/0000-0003-3198-6063)
- Nabil El Ayoubi (ORCID: https://orcid.org/0000-0003-0476-0990)
- Grace Fayad
Institutions
- American University of Beirut Medical Center (LB)
- American University of Beirut (LB)
Publication Details
- Journal
- BMC Medical Imaging
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1186/s12880-025-01897-6
- Citations
- 2
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94