Corneal stromal microdots accumulation and its association with corneal neurodegeneration and retinal microvascular perfusion in diabetes
Patients with DM demonstrated a significant increase of deposition of microdots in corneal stroma which correlates with corneal nerve loss and retinal microvascular perfusion. Microdots are at least partially composed of lipofuscin which is also observed in corneal basal epithelial layer.
Authors
- Xin Jin (ORCID: https://orcid.org/0000-0001-7300-828X)
- Zonghua Wang (ORCID: https://orcid.org/0000-0002-0869-9683)
- Jingrao Wang
- Hong Zhang (ORCID: https://orcid.org/0000-0002-8215-8105)
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-27
- DOI
- https://doi.org/10.3389/fendo.2025.1481018
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China