More Than Rapid Eye Movement Sleep Behavior Disorder: Sleep Differences in Parkinson’s Disease LRRK2 and GBA Genotypes
<i>LRRK2</i> PD is associated with less fragmented sleep than <i>GBA</i> PD and iPD, suggesting that despite similar objective sleep complaints, genotypic sleep differences extend beyond RBD. These differences support the need for personalized and genotypic approaches to sleep disturbances in PD. The absence of phase advancement in all groups suggests that lighting interventions to improve sleep disorders should be considered for the morning rather than later in the day.
Authors
- Barbara Plitnick (ORCID: https://orcid.org/0009-0006-8048-1546)
- Susan Bressman (ORCID: https://orcid.org/0000-0002-3513-8048)
- Rachel Saunders‐Pullman (ORCID: https://orcid.org/0000-0001-8132-8806)
- Deborah Raymond (ORCID: https://orcid.org/0000-0003-1403-7739)
- Mariana G. Figueiro (ORCID: https://orcid.org/0000-0002-7773-9239)
- Adina Wise (ORCID: https://orcid.org/0000-0002-3982-8505)
- Amy Astefanous
- AF Cohen
- Casey Young
- M. Yang (ORCID: https://orcid.org/0000-0003-2822-2476)
- Melba Beltre
Institutions
- Mount Sinai Beth Israel (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Sleep Medicine
- Published
- 2025-08-27
- DOI
- https://doi.org/10.13078/jsm.250016
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke