External validation of the COLOFIT colorectal cancer risk prediction model in the Oxford-FIT dataset: the importance of population characteristics and clinically relevant evaluation metrics
The potential benefit of COLOFIT varied depending on FIT testing rates, the proportion of FIT ≥ 10 µg/g, and the symptoms in the tested population. Adopting COLOFIT into current clinical practice demands, therefore, FIT positivity of at least 17% and CRC rates within 1.3-1.6%. Further validation in local and different populations would also be of significant value and help to maximise COLOFIT's ability to improve diagnostic pathways.
Authors
- Colin John Rees (ORCID: https://orcid.org/0000-0003-3050-8473)
- Kinga A. Várnai (ORCID: https://orcid.org/0000-0001-5695-9497)
- Brian David Nicholson (ORCID: https://orcid.org/0000-0003-0661-7362)
- Gary Abel (ORCID: https://orcid.org/0000-0003-2231-5161)
- Jim Davies (ORCID: https://orcid.org/0000-0003-4664-6862)
- Hizni Salih (ORCID: https://orcid.org/0000-0002-5283-7799)
- Eva Morris (ORCID: https://orcid.org/0000-0002-1075-6544)
- Brian Shine (ORCID: https://orcid.org/0000-0002-1016-8638)
- Theresa Noble (ORCID: https://orcid.org/0000-0002-4984-2538)
- Joshua Withers
- Tim James (ORCID: https://orcid.org/0000-0002-5382-9838)
- Andres Tamm (ORCID: https://orcid.org/0000-0003-0770-998X)
- William Hamilton (ORCID: https://orcid.org/0000-0003-1611-1373)
- James E. East (ORCID: https://orcid.org/0000-0001-8035-3700)
Institutions
- University of Exeter (GB)
- John Radcliffe Hospital (GB)
- Open Data Institute (GB)
- University of Oxford (GB)
- South Tyneside and Sunderland NHS Foundation Trust (GB)
- Oxford BioMedica (United Kingdom) (GB)
- Newcastle University (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1186/s12916-025-04339-w
- Citations
- 2
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Cancer Research UK
- National Institute for Health and Care Research
- Engineering and Physical Sciences Research Council
- NIHR Oxford Biomedical Research Centre