<scp> <i>TARDBP</i> </scp> ( <scp>TDP</scp> ‐43) Knock‐in Zebrafish Display a Late‐Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons
These novel models of common TDP-43 disease variants provide a unique opportunity to further our understanding of neurodegeneration in vivo and demonstrate that mutations in the same protein and domain can manifest with different phenotypes. ANN NEUROL 2026;99:178-197.
Authors
- Guy A. Rouleau (ORCID: https://orcid.org/0000-0001-8403-1418)
- Esteban C. Rodríguez
- Sabrina Semmler (ORCID: https://orcid.org/0000-0001-7422-9068)
- Christine Vande Velde (ORCID: https://orcid.org/0000-0001-5926-1529)
- Gary A.B. Armstrong (ORCID: https://orcid.org/0000-0003-4613-8817)
- Christian J. Rampal
- Virginie Petel Légaré (ORCID: https://orcid.org/0000-0003-0544-0905)
- Jay P. Ross (ORCID: https://orcid.org/0000-0002-8183-2524)
- Alexandra Lissouba
- Meijiang Liao
- Ziyaan A. Harji
Institutions
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1002/ana.78012
- Citations
- 2
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- ALS Society of Canada
- Weston Family Foundation
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Fonds de recherche du Québec
- Canadian Institutes of Health Research