Resveratrol mitigates aspirin-induced intestinal injury in rats in a high-altitude hypoxic environment associated with reducing the expression levels of angiotensin II
Resveratrol can effectively mitigate intestinal injury induced by aspirin at high altitude in hypoxic environments. The mechanism may involve downregulating the expression of Ang-II and ICAM-1, alleviating oxidative stress and the inflammatory response of the intestinal mucosa, and preserving intestinal barrier function.
Authors
- Feng Gao (ORCID: https://orcid.org/0000-0002-3320-5702)
- Yingying Xing (ORCID: https://orcid.org/0000-0001-5566-3096)
- Zhuo shuyi Liu
- Wen Hui Shi (ORCID: https://orcid.org/0000-0002-5106-4923)
- Jiang Wei Liu
- Weidong Liu (ORCID: https://orcid.org/0000-0003-3320-3958)
- Huan Liu (ORCID: https://orcid.org/0000-0002-5077-3648)
- Kailibinuer Nuermaimaiti
- Kudelaiti Abdukelimu
- Ailifeire Tuerxuntayi
- Paziliya Abulaiti
- Najimangu Rehemutula
Institutions
- Shihezi University (CN)
- Xinjiang Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Urumqi General Hospital of PLA (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1186/s12876-025-04248-5
- Citations
- 1
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Xinjiang