Decoupling transcriptome layers: the distinct and variable nature of circular RNAs
In both MDM and tissue samples, circular and linear transcriptomes follow distinct and largely independent regulatory logics. While both capture inter-individual variation, circRNA expression appears more variable and may carry fewer physiological signals, especially when no clear phenotypic signature has been detected in the corresponding linear transcriptome. These findings demonstrate that circular and linear RNAs arise from complementary and nonredundant layers of gene regulation, emphasizing the importance of analyzing both in parallel.
Authors
- Beatriz Gutiérrez‐Gil (ORCID: https://orcid.org/0000-0001-7990-5723)
- Patrice Déhais
- Thomas Faraut (ORCID: https://orcid.org/0000-0001-5156-3434)
- María Alonso-García (ORCID: https://orcid.org/0000-0002-4099-1553)
- Annie Robic (ORCID: https://orcid.org/0000-0003-3071-8614)
- Laurence Liaubet (ORCID: https://orcid.org/0000-0003-0201-0264)
- Julie Demars (ORCID: https://orcid.org/0000-0003-2451-0059)
- Christa Kühn
Institutions
- Friedrich-Loeffler-Institut (DE)
- École Nationale Vétérinaire de Toulouse (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Département mathématiques, informatique, sciences de la donnée et technologies du numérique (FR)
- Research Institute for Farm Animal Biology (FBN) (DE)
- Génétique Physiologie et Systèmes d'Elevage (FR)
- Universidad de León (ES)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1186/s12915-025-02375-9
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81