Association of adipokines and sleep disorders among the 25—44 year-old people

Objective. To analyze the associations of adipokine levels (leptin, adiponectin) and sleep disorders as independent risk factors for cardiovascular diseases in residents of Novosibirsk aged 25—44 years. Materials and methods. A random representative sample of individuals aged 25—44 years (975 subjects of both sexes, the response rate was 71%) in Novosibirsk was assessed (using standard methods of the WHO MONICA-psychosocial program). Sleep disorders were assessed using the sleep disorders scale included in the WHO MONICA-psychosocial protocol in 2013—2016 at the Institute of Internal and Preventive Medicine, a branch of the federal research center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences; biochemical tests to measure the level of adipokines were performed in the laboratory of clinical biochemical and hormonal studies of therapeutic diseases. Results. Sleep disorders were detected in 12% of respondents of both sexes, and in women, they were twice as common as in men. The median blood leptin level and leptin/adiponectin index were higher in individuals with sleep disorders, and the lowest in respondents without sleep disorders. The median adiponectin level was higher in individuals without sleep disorders and lower in individuals with sleep disorders. There was an increase in the rate of sleep disorders with an increase in the leptin level, and vice versa. Conclusion. Sleep disorders were detected in 12% of respondents aged 25—44, and in women, they were twice as common as in men. Subjects with sleep disorders had higher blood leptin levels, a higher leptin/adiponectin index, and lower adiponectin levels compared to subjects without sleep disorders.