Electrochemically Promoted Three-Component Synthesis for the Functionalization of <i>N</i>-Sulfonylformamidine
A one-pot synthetic strategy was developed by using electrochemical methods to convert sulfonamides into <i>N</i>-sulfonylformamidines, followed by the direct functionalization of the C-H bond through Shono oxidation. Subsequently, modification was achieved by introducing azide groups via imide ions under Lewis acid catalysis, utilizing TMSN<sub>3</sub> as the nucleophilic reagent. This strategy is compatible with a wide range of functional groups, and its utility has been demonstrated through scale-up experiments and derivatization reactions.
Authors
- Li‐Rong Wen (ORCID: https://orcid.org/0000-0001-7976-0878)
- Lin‐Bao Zhang (ORCID: https://orcid.org/0000-0002-8334-4188)
- Weisi Guo (ORCID: https://orcid.org/0000-0001-6688-4679)
- Li-Ming Zhang (ORCID: https://orcid.org/0000-0002-3376-7051)
- Yi-Le Song
- Shi-Jie Bo
- Ming Li (ORCID: https://orcid.org/0000-0003-4906-936X)
- Jiaxiu Liu
- Xue-Yang Guo
Institutions
- Qingdao University of Science and Technology (CN)
- State Key Laboratory of Chemical Engineering (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1021/acs.joc.5c01686
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China