Generation of human induced pluripotent stem cell lines from healthy Korean donors (IPBi101-A, IPBi102-A, IPBi103-A, IPBi105-A, IPBi107-A, IPBi108-A, IPBi110-A, IPBi111-A, IPBi113-A, and IPBi114-A)
Human induced pluripotent stem cell (iPSC) lines were derived from peripheral blood mononuclear cells (PBMCs) obtained from ten healthy Korean donors of diverse ages and genders using a Sendai virus-based reprogramming method. These iPSC lines expressed markers of undifferentiated state and demonstrated trilineage differentiation potential in vitro. Characterization confirmed normal karyotypes, clearance of the Sendai virus, and short tandem repeat (STR) profiles identical to the parental PBMCs. These cell lines can serve as a valuable resource for disease modeling, drug screening, and as a human-based alternative to animal experiments.
Authors
- Jihwan Song (ORCID: https://orcid.org/0000-0002-6597-8208)
- Yeul Hong Kim (ORCID: https://orcid.org/0000-0002-2555-2333)
- J.J. Park
- Chan Yeong Heo (ORCID: https://orcid.org/0000-0001-9003-7365)
- Mahito Nakanishi
- Miju Lee (ORCID: https://orcid.org/0009-0000-9307-2705)
- Seong‐Su Nah
- Mira Han (ORCID: https://orcid.org/0000-0002-0488-1170)
Institutions
- Institut Pasteur Korea (KR)
- University of Tsukuba (JP)
- Seoul National University Bundang Hospital (KR)
- CHA University (KR)
- NC bit (South Korea) (KR)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1016/j.scr.2025.103821
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Food and Drug Safety