Cryoglobulinemic vasculitis in patients with viral hepatitis C. Does viral eradication always lead to a complete clinical and immunological response?

Mixed cryoglobulinemiа is one of the common extrahepatic manifestations of chronic viral hepatitis C. According to the research results, about 53% of HCV patients have cryoglobulins in their blood serum. This article analyzes the results of scientific papers by a number of authors who have studied the effectiveness of antiviral treatment in patients with cryoglobulinemia. The purpose of the article is to reveal a number of questions: is there a link between the presence of mixed cryoglobulinemia and liver fibrosis in patients? Will virus eradication always lead to a complete clinical and immunological response? The authors concluded that the presence of mixed cryoglobulinemia is associated with severe liver fibrosis (F3 and F4), which may allow cryoglobulinemia to be considered an immunological indicator of cirrhosis. Diagnostic alertness for patients should be maintained even after achieving a sustained virological response, since a complete immunological response.