MUlticentre REtrospective comparison of definitive EBRT with or without HDR BRAchytherapy boost in patients with locally-advanced prostate cancer and regional lymph NOde metastases (MUREBRANO) – A propensity score matched analysis
BT-boost was not associated with improved outcomes in unselected patients treated with ADT and EBRT for clinically node-positive prostate cancer. However, subset analysis indicated that BT-boost was associated with improved outcomes in patients with ISUP grade 4-5 disease, and patients treated with BT-boost had lower rates of moderate or worse GI toxicity. Prospective studies are necessary to validate these findings.
Authors
- Tomasz Bajon
- Andrzej Kukiełka (ORCID: https://orcid.org/0000-0001-9940-0204)
- Mateusz Bilski (ORCID: https://orcid.org/0000-0002-4962-3028)
- Adam Kluska (ORCID: https://orcid.org/0000-0001-9933-3646)
- Rafał Stando (ORCID: https://orcid.org/0000-0002-2543-8370)
- Artur J. Chyrek (ORCID: https://orcid.org/0000-0003-3062-8395)
- Robert Matys
- Piotr Lelek
- Matthias Moll (ORCID: https://orcid.org/0000-0001-5523-8866)
- Piotr Wojcieszek (ORCID: https://orcid.org/0000-0002-8347-4142)
- Maciej Trojanowski (ORCID: https://orcid.org/0000-0002-9124-1509)
- Marcin Miszczyk (ORCID: https://orcid.org/0000-0002-4375-0827)
- Katarzyna Konat-Bąska (ORCID: https://orcid.org/0000-0002-4506-2411)
- Magdalena Stankiewicz (ORCID: https://orcid.org/0000-0002-2608-1959)
- Adam Chicheł (ORCID: https://orcid.org/0000-0001-6354-5030)
- Shahrokh François Shariat (ORCID: https://orcid.org/0000-0002-6627-6179)
- Wojciech Burchardt (ORCID: https://orcid.org/0000-0002-0013-8881)
- Aleksandra Napieralska (ORCID: https://orcid.org/0000-0002-7390-9165)
- Alfonso Gómez‐Iturriaga (ORCID: https://orcid.org/0000-0002-1094-5839)
- Paweł Cisek (ORCID: https://orcid.org/0000-0001-8375-5289)
- Michał Dec
- E. Piliszczuk
Institutions
- Medical University of Lublin (PL)
- Cornell University (US)
- Koszalin University of Technology (PL)
- University of Business and Administration in Gdynia (PL)
- BioCruces Health research Institute (ES)
- Comprehensive Cancer Center Vienna (AT)
- Greater Poland Cancer Center (PL)
- National Institute of Oncology (HU)
- Holy Cross University (PL)
- Gdynia Maritime University (PL)
- Lublin Oncology Center (PL)
- Stocznia Gdynia (Poland) (PL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- MedAustron (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1016/j.radonc.2025.111112
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- Astellas Pharma