Peripheral Vasopressor Use in Early Sepsis-Induced Hypotension
In this prospective cohort study of the CLOVERS trial, peripheral administration of vasopressors was common and was associated with low complication rates. These findings support the safety and feasibility of short-term peripheral vasopressor use in early sepsis resuscitation.
Authors
- Mitchell M. Levy (ORCID: https://orcid.org/0000-0001-8556-2405)
- Rebekah Peacock
- Raghu R. Seethala (ORCID: https://orcid.org/0000-0002-3501-7094)
- Manuel Hache Marliere
- Kimia Ashktorab (ORCID: https://orcid.org/0000-0001-6262-7560)
- Kiran Ashok
- Jarrod Mosier (ORCID: https://orcid.org/0000-0002-5371-0845)
- Rilee Smith
- Cameron Hypes
- Julie A. Wallick (ORCID: https://orcid.org/0000-0002-4568-4704)
- John Eppensteiner
- Christian Sandrock
- Ashley Montgomery-Yates (ORCID: https://orcid.org/0000-0003-2245-1219)
- Marjolein de Wit
- Mark D. Williams (ORCID: https://orcid.org/0000-0002-3580-2818)
- Karen Bienstock
- Valerie Banner‐Goodspeed (ORCID: https://orcid.org/0000-0002-7644-2521)
- Quinn Montgomery
- Andrew Goodwin (ORCID: https://orcid.org/0000-0002-6543-9458)
- Marie Childs Sandi
- Joseph R. Bledsoe (ORCID: https://orcid.org/0000-0002-3005-2878)
- Chadwick D. Miller (ORCID: https://orcid.org/0000-0002-4362-4409)
- Megan Fuentes
- Marc L. Schermerhorn (ORCID: https://orcid.org/0000-0002-4278-964X)
- Carolyn Brokowski
- Jakea Johnson
- Ani Aydin (ORCID: https://orcid.org/0000-0002-9470-1953)
- Evan Cassity
- Gregory W. Hendey (ORCID: https://orcid.org/0000-0002-0170-8743)
- Natalie Pulido
- Adrienne Baughman
- Mark Tidswell (ORCID: https://orcid.org/0000-0001-6333-6810)
- Jen‐Ting Chen (ORCID: https://orcid.org/0000-0002-8530-2520)
- Lindsay M. Leither
- José L. Meza
- Ithan D. Peltan (ORCID: https://orcid.org/0000-0003-1730-234X)
- Matthew E. Prekker (ORCID: https://orcid.org/0000-0002-3969-3022)
- Terra Hiller (ORCID: https://orcid.org/0000-0002-8215-1480)
- Eric Jaton (ORCID: https://orcid.org/0000-0002-2337-5820)
- Susan Jackman
- Robert C. Hyzy (ORCID: https://orcid.org/0000-0003-1890-4932)
- D. Clark Files (ORCID: https://orcid.org/0000-0002-1595-4080)
- Abhijit Duggal (ORCID: https://orcid.org/0000-0003-4220-2359)
- Cynthia Oliva (ORCID: https://orcid.org/0000-0001-5936-2530)
- Christopher Michael Jason Cox (ORCID: https://orcid.org/0000-0001-5210-5451)
- David T. Huang (ORCID: https://orcid.org/0000-0002-9165-7643)
- Jay S. Steingrub (ORCID: https://orcid.org/0000-0002-6019-6725)
- Scott T. Youngquist (ORCID: https://orcid.org/0000-0002-2343-9521)
- Andrew Bouffler
- Marie‐Carmelle Elie (ORCID: https://orcid.org/0000-0002-4807-9403)
- Kendall M. Lavin-Parsons
- Brent Armbruster
- Katherine Piserchia
- Michelle Freemer
- Lindsey Waddoups
- Megan E. Rowland (ORCID: https://orcid.org/0009-0000-2967-2992)
- Lori Flores (ORCID: https://orcid.org/0000-0001-6118-1448)
- James Chenoweth (ORCID: https://orcid.org/0000-0001-9537-0116)
- Blair A. Parry (ORCID: https://orcid.org/0000-0002-6230-5286)
- Audrey Hendrickson
- Thomas O’Mara (ORCID: https://orcid.org/0000-0002-5310-0254)
- Siddharth Dugar (ORCID: https://orcid.org/0000-0002-3243-1417)
- Sinan Hanna
- James P. Kiley
- Jenny G Wilson
- EVAN L RAMSER
- Charles R. Terry (ORCID: https://orcid.org/0000-0001-5457-6265)
- Lauren Kunz
- Michelle Howell (ORCID: https://orcid.org/0000-0002-8748-2641)
- Charles Wira (ORCID: https://orcid.org/0000-0002-1041-4165)
- Mary LaRose
- Neal W. Dickert (ORCID: https://orcid.org/0000-0003-4415-3861)
- Henry E. Wang (ORCID: https://orcid.org/0000-0002-4738-0093)
- Norman Olbrich
- Daniel Brodie (ORCID: https://orcid.org/0000-0002-0813-3145)
- Jesse Hall
- Jennifer A. Frey
- Hallie C. Prescott (ORCID: https://orcid.org/0000-0002-8442-6724)
- James H. Paxton (ORCID: https://orcid.org/0000-0003-2154-4472)
- Adit A. Ginde (ORCID: https://orcid.org/0000-0003-2325-206X)
- Utsav Nandi (ORCID: https://orcid.org/0000-0003-3833-6194)
- Colin D. Campbell (ORCID: https://orcid.org/0000-0002-5163-7656)
- Neil R. Aggarwal (ORCID: https://orcid.org/0000-0002-0922-8824)
- Sarah Seelye (ORCID: https://orcid.org/0000-0001-5098-7470)
- William Nkemdirim
- Jonathan Siner
- Deborah B. Diercks (ORCID: https://orcid.org/0000-0003-2043-7405)
- Peter E. Morris
- Jeffrey McKeehan
- Sarah Gerard Dean (ORCID: https://orcid.org/0000-0002-3682-5149)
- Mario Stylianou
- James Galbraith (ORCID: https://orcid.org/0000-0003-4325-3836)
- Roy G. Brower
- Caitlan Lematty
- Makrina Kamel
- Samuel Acquah (ORCID: https://orcid.org/0000-0002-6947-1359)
- L. Precopio
- Thanh Huyền Trần (ORCID: https://orcid.org/0000-0003-3191-0413)
- Maranda Newton
- Wesley H. Self (ORCID: https://orcid.org/0000-0002-9300-3045)
- Omar Mehkri (ORCID: https://orcid.org/0000-0002-6669-0265)
- Emily E. Petersen (ORCID: https://orcid.org/0000-0003-1989-1694)
- Nathan Ivan Shapiro (ORCID: https://orcid.org/0000-0003-3508-4390)
- Charles B. Cairns (ORCID: https://orcid.org/0000-0003-2291-5415)
- Richard G. Wunderink (ORCID: https://orcid.org/0000-0002-8527-4195)
- Lisa Kurt
- Pauline K. Park (ORCID: https://orcid.org/0000-0002-5972-4340)
- Sharon Hayes (ORCID: https://orcid.org/0000-0002-5756-6051)
- Mark Sochor
- Laurie Zoloth (ORCID: https://orcid.org/0000-0001-8751-7261)
- Jonathan D. Casey (ORCID: https://orcid.org/0000-0002-0977-290X)
- Hayley Morin
- Sara Keegan
- Stacy A. Trent (ORCID: https://orcid.org/0000-0001-9384-7400)
- Kevin W. Gibbs (ORCID: https://orcid.org/0000-0002-5272-2289)
- Sabah Boujid
- Lora A. Reineck
- Enrique Marcos Sierra Benítez (ORCID: https://orcid.org/0000-0001-6321-6413)
- David Schoenfeld (ORCID: https://orcid.org/0000-0003-1948-3711)
- Jason R. Mock (ORCID: https://orcid.org/0000-0002-7022-0629)
- Connie Romaine
- Jamie Sturgill (ORCID: https://orcid.org/0000-0001-8856-3227)
- Ebaad Haq
- Michael A. Puskarich (ORCID: https://orcid.org/0000-0001-6358-4670)
- Kristine Nelson
- Cynthia Kardos
- Paula Lauto
- Raj Kapoor
- Nicholas J. Johnson (ORCID: https://orcid.org/0000-0001-9915-0591)
- Mark Siegel
- Christine A. Ulysse
- Todd W. Rice (ORCID: https://orcid.org/0000-0002-7136-5408)
- Sam Torbati (ORCID: https://orcid.org/0000-0001-8424-8764)
- R. Duncan Hite (ORCID: https://orcid.org/0000-0002-2625-8750)
- Catherine L. Hough (ORCID: https://orcid.org/0000-0001-6425-0867)
- Jakob I. McSparron (ORCID: https://orcid.org/0000-0003-4968-8734)
- Bryce R. H. Robinson
- Sarah Karow
- Dakota D. Fletcher
- Nancy Ringwood
- Michael A. Matthay (ORCID: https://orcid.org/0000-0003-3039-8155)
- Michael D. Hellman (ORCID: https://orcid.org/0000-0001-7411-0067)
- Kyle B. Enfield (ORCID: https://orcid.org/0000-0003-4624-0176)
- Joshua A. Englert (ORCID: https://orcid.org/0000-0002-1257-2239)
- Charlotte Kirk
- José Víctor Jiménez (ORCID: https://orcid.org/0000-0002-9209-0327)
- Brigitte M. Borg (ORCID: https://orcid.org/0000-0002-6412-3670)
- Kathryn A. Hibbert (ORCID: https://orcid.org/0000-0001-7908-5446)
- Elizabeth A. Middleton (ORCID: https://orcid.org/0000-0002-5120-8202)
- Torben K. Becker (ORCID: https://orcid.org/0000-0002-5287-8056)
- Timothy E. Albertson (ORCID: https://orcid.org/0000-0001-5724-3300)
- Steven Y. Chang (ORCID: https://orcid.org/0000-0002-7365-5265)
- Matthew R. Lammi (ORCID: https://orcid.org/0000-0001-5125-1801)
- Michelle N. Gong (ORCID: https://orcid.org/0000-0001-7952-5384)
- Justin Belsky (ORCID: https://orcid.org/0000-0002-3711-0954)
- Eugenia Quackenbush (ORCID: https://orcid.org/0000-0002-9872-1396)
- George Lim
- Jonasel Roque
- Nicholas J. Horton (ORCID: https://orcid.org/0000-0003-3332-4311)
- Neha Goel (ORCID: https://orcid.org/0000-0001-7295-2033)
- Ariela Muzikansky
- Niree Hindoyan
- Jessica Mason (ORCID: https://orcid.org/0000-0003-3892-5941)
- Alyssa Hughes
- Lawrence E. Kass (ORCID: https://orcid.org/0000-0002-2190-7299)
- Nathaniel Marchetti (ORCID: https://orcid.org/0000-0003-3229-8879)
- David Kung‐Chun Chiu (ORCID: https://orcid.org/0000-0002-9700-4707)
- Nicole M. Dubosh (ORCID: https://orcid.org/0000-0001-8674-5334)
- Derek W. Russell (ORCID: https://orcid.org/0000-0002-2716-1344)
- Michael R. Filbin (ORCID: https://orcid.org/0000-0002-2588-7504)
- Christopher Fung (ORCID: https://orcid.org/0000-0003-3585-1385)
- Patrick Maher (ORCID: https://orcid.org/0000-0002-4860-8643)
- Lesley De Souza
- Howard A Smithline (ORCID: https://orcid.org/0000-0001-6972-5833)
- Paige A. DeVries
- Michael A. Turturro
- Akram Khan (ORCID: https://orcid.org/0000-0003-3091-632X)
- Elizabeth Salvagio Campbell
- Amber E. Plante (ORCID: https://orcid.org/0000-0002-1010-2348)
- Ian G. Stiell (ORCID: https://orcid.org/0000-0002-2583-6408)
- Angela J. Rogers (ORCID: https://orcid.org/0000-0001-6969-6200)
- Ryan Huebinger (ORCID: https://orcid.org/0000-0002-9448-5744)
- Bela Patel (ORCID: https://orcid.org/0000-0001-5804-5226)
- Kostas Andreo
- Abbey Staugaitis
- Samuel Morris Brown (ORCID: https://orcid.org/0000-0003-1206-6261)
- Joseph E. Levitt (ORCID: https://orcid.org/0000-0001-5316-4971)
- Jordan Schooler
- Sarah Romain
- Bryan J. McVerry (ORCID: https://orcid.org/0000-0002-1175-4874)
- Erin Hardy
- Imoigele P. Aisiku (ORCID: https://orcid.org/0000-0003-1041-3768)
- Helen K. Donnelly (ORCID: https://orcid.org/0000-0001-8827-8581)
- Lynne D. Richardson (ORCID: https://orcid.org/0000-0002-5425-1601)
- Sarah Katsandres
- Lauren E. Ferrante (ORCID: https://orcid.org/0000-0003-1345-1225)
- Mary Faith Marshall (ORCID: https://orcid.org/0009-0009-7822-5326)
- Adrian Lagakos
- Laurie J. Morrison (ORCID: https://orcid.org/0000-0001-8369-9774)
- Sherell Thornton‐Thompson
- Melissa Fergus
- Kelly Harrison
- Carolynn Lyle (ORCID: https://orcid.org/0000-0001-5083-6031)
- Darrin Applegate
- Pierre Arsenault
- Rebecca M. Baron (ORCID: https://orcid.org/0000-0003-1673-9523)
- Weixing Huang (ORCID: https://orcid.org/0009-0009-5279-394X)
- Sean D. McGarry (ORCID: https://orcid.org/0000-0003-4937-2780)
- Sandipan Dhar (ORCID: https://orcid.org/0000-0002-9304-2212)
- Jason J. Bischof (ORCID: https://orcid.org/0000-0001-5950-130X)
- Cathryn F. Oldmixon
- Richard J. Kryscio (ORCID: https://orcid.org/0000-0002-2775-1184)
- Adam Breslin
- Colleen Rice (ORCID: https://orcid.org/0000-0001-5387-5802)
- Andre De Souza Licht
- Jason S. Haukoos (ORCID: https://orcid.org/0000-0001-7784-6811)
- Kusum S. Mathews (ORCID: https://orcid.org/0000-0002-8810-2794)
- Ivor S. Douglas (ORCID: https://orcid.org/0000-0002-4541-1431)
- Rebecca M. Beutler
- Kinsley Hubel (ORCID: https://orcid.org/0000-0001-6015-4472)
- Alexander T. Limkakeng (ORCID: https://orcid.org/0000-0002-9822-5595)
- Hiwet Tzehaie
- Jamie Stang (ORCID: https://orcid.org/0000-0002-3402-1067)
- Jason D. Christie (ORCID: https://orcid.org/0000-0003-0519-218X)
- Rosemary Vojnik
- Olivia Krol
- Daniel Talmor (ORCID: https://orcid.org/0000-0002-7239-8068)
- Lani Finck
- Robert Paine (ORCID: https://orcid.org/0000-0002-4511-4437)
- Lauren E. Koehler
- Allen T. Grady
- Matthew C. Exline (ORCID: https://orcid.org/0000-0001-6797-158X)
- Nina Gentile (ORCID: https://orcid.org/0000-0002-1222-5966)
- Brenda López
- Elizabeth S. Munroe (ORCID: https://orcid.org/0000-0003-3353-612X)
- Robert R. Ehrman (ORCID: https://orcid.org/0000-0001-9730-8471)
- Kimberly Yee (ORCID: https://orcid.org/0000-0002-3703-1367)
- Anika Agrawal (ORCID: https://orcid.org/0000-0001-7465-2771)
- Shane O’Mahony
- Damon C. Scales (ORCID: https://orcid.org/0000-0001-7101-3958)
- Peter Hou
- Nida Qadir (ORCID: https://orcid.org/0000-0001-7791-049X)
- D. Mark Courtney (ORCID: https://orcid.org/0000-0002-0905-465X)
- Ari Moskowitz (ORCID: https://orcid.org/0000-0002-0194-990X)
- Bhupinder Natt (ORCID: https://orcid.org/0000-0002-3871-0513)
- Milad Karami Jouzestani
- Scott Oullette
- Myron Maclawiw
- Peter Chen (ORCID: https://orcid.org/0000-0002-5330-1718)
- David B. Page (ORCID: https://orcid.org/0000-0002-7493-8486)
- Thomas E. Terndrup (ORCID: https://orcid.org/0000-0003-4376-2593)
- Amira Mohamed (ORCID: https://orcid.org/0009-0002-8381-1265)
- Alan E. Jones (ORCID: https://orcid.org/0000-0001-5772-6222)
- Shannon S. Carson (ORCID: https://orcid.org/0000-0001-7983-1410)
- Rahul Nair (ORCID: https://orcid.org/0000-0002-1875-2409)
- Polly E. Parsons
- Ejigayehu Demissie
- Ronald A. Reilkoff
- Andrea Tam (ORCID: https://orcid.org/0009-0001-7726-2397)
- Margaret Hays
- Poying Lai
- Ashley Simpson
- Alexandra Weissman
- Derek Angus
- Ithan D. Peltan
- Kristin Hudock (ORCID: https://orcid.org/0000-0001-5429-3687)
- Skyler J Pearson
- Gail Weinmann
- J. A. Nash
- Rachel Gropper
- John Wilburn
- Laura Fitzgerald
- Bennett P. deBoisblanc
- Kyle Happel
- Carrie Higgins
- Stephanie Gravitz
- Donna S. Harris
- Kathleen Rebelo de Sousa
- Donald M. Yealy
- John Sather
- Estelle S. Harris
- Ivan Co
- Anthony F. Massaro
- Kelsey Jiang
- Elizabeth Vidales
- Valerie Aston
- Hannah Reimer
- Matthew Shaw
- Samuel Whitaker
- M. West
- D Janz
- Aamer Syed (ORCID: https://orcid.org/0000-0002-7499-3725)
- Ana Garcia
- Robert Sherwin
- Marc Moss
- Lori Kozikowski
- Andrei Hastings
- Richard P. Morse
- Stephanie Gundel
- Opeolu Adeoye
- Katherine Boyle
- S. Pugh
- Eyad Almarsi
- Meghan Willig
- Autumn Cresie
- Stephanie Stoianoff
- Sakshi Seghal
- Zach Zouyed
- Alexandra Duven
- B. Taylor Thomspon
- Eric Hyder
- Ted Raddell
- Lihini Keenawinna
- David Miru
- Pam Sigel
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Oregon Health & Science University (US)
- Vanderbilt University (US)
- University of Michigan (US)
- Denver Health Medical Center (US)
- Intermountain Medical Center (US)
- Library Network (US)
- VA Center for Clinical Management Research (US)
- Vanderbilt University Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.29148
- Citations
- 9
- Primary Topic
- Hemodynamic Monitoring and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 18.06
Funders
- U.S. Department of Veterans Affairs
- Vanderbilt University
- Vanderbilt University Medical Center
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- NIH Clinical Center
- National Center for Advancing Translational Sciences