Antipsychotic Drugs and Dysregulated Glucose Homeostasis
In this systematic review and meta-analysis, results indicate that AP exposure significantly disrupts glucose homeostasis independent of exposure time, dose, diagnosis, and weight gain propensity. Increased awareness of AP-induced dysregulations in glucose homeostasis alongside ongoing metabolic monitoring and potential treatment is warranted.
Authors
- Zachary Freyberg (ORCID: https://orcid.org/0000-0001-6460-0118)
- Jacob S. Ballon (ORCID: https://orcid.org/0000-0002-6157-4847)
- Andrew Ji
- Jonathan Monteiro (ORCID: https://orcid.org/0000-0002-7045-971X)
- Margaret Hahn (ORCID: https://orcid.org/0000-0001-8884-9946)
- Kateryna Maksyutynska
- Tyler R. Prestwood (ORCID: https://orcid.org/0000-0002-0971-5286)
- Femin Prasad (ORCID: https://orcid.org/0000-0002-5445-2489)
- Sri Mahavir Agarwal (ORCID: https://orcid.org/0000-0002-2705-5146)
- Kristoffer Panganiban
- Kaitlin Fuller (ORCID: https://orcid.org/0000-0002-8315-187X)
- Samantha Cavalier
- Emril Radoncic
- Jiwon Lee (ORCID: https://orcid.org/0000-0002-8456-684X)
- Zilu Yang (ORCID: https://orcid.org/0009-0007-1140-769X)
- Michael J. McCarthy (ORCID: https://orcid.org/0000-0001-6219-4945)
- Christoph U. Correll (ORCID: https://orcid.org/0000-0001-5720-7203)
- Emily C. C. Smith
- Divia Shah
- Reva U. Prabhune
Institutions
- Northwell Health (US)
- Centre for Addiction and Mental Health (CA)
- University of Pittsburgh (US)
- University of Toronto (CA)
- St. Francis Xavier University (CA)
- University of California San Diego (US)
- Diabetes Canada (CA)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Zucker Hillside Hospital (US)
- Charité - Universitätsmedizin Berlin (DE)
- Stanford University (US)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1001/jamapsychiatry.2025.2240
- Citations
- 4
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.88