Low Measles Seropositivity in Vaccinated Children
In this cross-sectional study, substantial measles immunity gaps were found despite high vaccine coverage with evidence of breakthrough infections, posing significant challenges to India's measles elimination efforts. These results underscore the urgent need to strengthen India's immunization program and investigate the mechanisms driving suboptimal responses to measles vaccination; without addressing these immune response deficiencies, achieving measles elimination through increased vaccine coverage alone may remain unattainable in India.
Authors
- Huy Quang Quach (ORCID: https://orcid.org/0000-0003-2191-5771)
- Inna G. Ovsyannikova (ORCID: https://orcid.org/0000-0003-1506-9214)
- Richard B. Kennedy
- Sara Pace Jones
- Diane E. Grill (ORCID: https://orcid.org/0000-0002-8677-1724)
- Remya Vasanthi Sasi
- Iype Joseph
- John B. Johnson (ORCID: https://orcid.org/0000-0003-4287-4489)
- Raji Prasad
- Nathaniel D. Warner (ORCID: https://orcid.org/0000-0001-9584-5257)
- Joshy Jacob (ORCID: https://orcid.org/0000-0003-0247-7016)
- Aaron Powell (ORCID: https://orcid.org/0000-0003-2963-0711)
- Gregory A. Poland
- M. Radhakrishna Pillai
- Remya Reveendran
- Archana Mohankumar Ajithakumari
- Jayalekshmi Devakikutty
- Vishnu Vikraman Mohanakumari
Institutions
- Mayo Clinic (US)
- Emory University (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Rajiv Gandhi Centre for Biotechnology (IN)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.29409
- Citations
- 1
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.35