Considerations and surgical approach to vitreous, retinal, and chorioretinal biopsy

Vitreous and chorioretinal biopsies may be required in atypical cases of intraocular inflammation that do not respond to treatment or do not respond as anticipated. A thorough differential diagnosis is important, allowing the surgeon to order and prioritize the appropriate testing for an obtained sample. As these samples can be limited or challenging to collect, it is also crucial that vitreoretinal surgeons optimize their diagnostic yield by communicating with various labs that are involved with sample processing.