The Role of Innate Immune System: A Crosstalk between Invertebrates and Humans

Innate immunity is the oldest form in evolution and is present in all multicellular organisms, including vertebrates and invertebrates. Although humans are the most recent evolutionary phylum, there is abundant evidence of a genetic inheritance shared between invertebrates and humans. There is correspondence between molecular pathways associated with the recognition systems of pathogen-associated molecular patterns (PAMPs) via pattern recognition receptors (PRRs) and Peptidoglycan recognition proteins (PGRPs). From a molecular point of view, intimate associations occur in key components of the molecular signaling process such as signal transducer and activator of transcription (STAT), Janus kinase (JAK), c-Jun N-terminal kinase (JNK), Toll-like receptor (TLR). Using these parallels is essential for a better understanding and conservation of living organisms, establishing essential biotechnological strategies for the progress of the understanding of the immune system.