Front Cover: Ring‐Rearrangement Driven Formal (3 + 2) Cycloaddition of Enaminone‐Based Thioalkynes with Nitriles to Form Thiazole Containing Bis‐Heterocycles (Eur. J. Org. Chem. 31/2025)
The Front Cover depicts a synthetic route for pharmaceutically important bis-heterocyclic 3,4-dihydropyridin-2(H)-one containing thiazole derivatives by triflic acid-mediated ring rearrangement and formal (3 + 2) cycloaddition reaction of enaminone-based thioalkynes with nitriles. The outcome of reaction is decided by the substitution pattern on the cyclohexenyl ring. The developed protocol is operationally simple with a shorter reaction time and features a wider substrate scope delivering a very good to excellent yield of products. More information can be found in the Research Article by K. N. Tiwari and co-workers (DOI: 10.1002/ejoc.202500287). Cover designed by K.N.T.
Authors
- Keshri Nath Tiwari (ORCID: https://orcid.org/0000-0001-5079-9453)
- Abha Sharma (ORCID: https://orcid.org/0000-0002-4401-0513)
- R. Chandran
Institutions
- Government Medical College (IN)
- Kerala University of Health Sciences (IN)
- National Institute of Pharmaceutical Education and Research (IN)
- Indrashil University (IN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1002/ejoc.70069
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00