Front Cover: Ring‐Rearrangement Driven Formal (3 + 2) Cycloaddition of Enaminone‐Based Thioalkynes with Nitriles to Form Thiazole Containing Bis‐Heterocycles (Eur. J. Org. Chem. 31/2025)

The Front Cover depicts a synthetic route for pharmaceutically important bis-heterocyclic 3,4-dihydropyridin-2(H)-one containing thiazole derivatives by triflic acid-mediated ring rearrangement and formal (3 + 2) cycloaddition reaction of enaminone-based thioalkynes with nitriles. The outcome of reaction is decided by the substitution pattern on the cyclohexenyl ring. The developed protocol is operationally simple with a shorter reaction time and features a wider substrate scope delivering a very good to excellent yield of products. More information can be found in the Research Article by K. N. Tiwari and co-workers (DOI: 10.1002/ejoc.202500287). Cover designed by K.N.T.

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Publication Details

Journal
European Journal of Organic Chemistry
Published
2025-08-22
DOI
https://doi.org/10.1002/ejoc.70069
Primary Topic
Click Chemistry and Applications
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article
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article

Front Cover: Ring‐Rearrangement Driven Formal (3 + 2) Cycloaddition of Enaminone‐Based Thioalkynes with Nitriles to Form Thiazole Containing Bis‐Heterocycles (Eur. J. Org. Chem. 31/2025)

Keshri Nath Tiwari, Abha Sharma, R. Chandran
European Journal of Organic Chemistry
Click Chemistry and Applications
article

Front Cover: Ring‐Rearrangement Driven Formal (3 + 2) Cycloaddition of Enaminone‐Based Thioalkynes with Nitriles to Form Thiazole Containing Bis‐Heterocycles (Eur. J. Org. Chem. 31/2025)

Keshri Nath Tiwari, Abha Sharma, R. Chandran
article en

Abstract

The Front Cover depicts a synthetic route for pharmaceutically important bis-heterocyclic 3,4-dihydropyridin-2(H)-one containing thiazole derivatives by triflic acid-mediated ring rearrangement and formal (3 + 2) cycloaddition reaction of enaminone-based thioalkynes with nitriles. The outcome of reaction is decided by the substitution pattern on the cyclohexenyl ring. The developed protocol is operationally simple with a shorter reaction time and features a wider substrate scope delivering a very good to excellent yield of products. More information can be found in the Research Article by K. N. Tiwari and co-workers (DOI: 10.1002/ejoc.202500287). Cover designed by K.N.T.

European Journal of Organic ChemistryVol. 28(31)
Government Medical College (IN), Kerala University of Health Sciences (IN), National Institute of Pharmaceutical Education and Research (IN), Indrashil University (IN)
Openalex Percentile: Top 83%
Click Chemistry and Applications
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