Oxidative rearrangement of indoles mediated by 2-bromoethanol and hydrogen peroxide to access spirooxindoles
Oxidative rearrangement of indoles into a series of spirooxindoles has been accomplished by using an exclusive reagent system containing 2-bromoethanol and hydrogen peroxide. This alternative metal-free approach features utilization of HOBr, generated <i>in situ</i> from the reaction of 2-bromoethanol and hydrogen peroxide <i>via</i> a radical pathway, as an electrophilic species to enable the spirolization to occur.
Authors
- Dongxue Yin
- Haofeng Shi
- Dan Xiao (ORCID: https://orcid.org/0000-0003-2484-1405)
- Kaiyue Yang
- Zhijian Wang (ORCID: https://orcid.org/0000-0002-9659-5242)
- Jiaxin He
- Yunfei Du (ORCID: https://orcid.org/0000-0002-0213-2854)
- Yingjie Gao (ORCID: https://orcid.org/0000-0002-6853-7870)
Institutions
- Tianjin University (CN)
- Tianjin Institute of Pharmaceutical Research (China) (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01126d
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00