The Neuroprotective Effects of Tea against γ-secretase Activity, APP Interactors, and tau-related Processes in Alzheimer's Disease: Insights from Caenorhabditis elegans Models

Alzheimer’s Disease (AD) is one of the most pervasive neurodegenerative diseases worldwide, marked by brain atrophy and neuronal loss. This study focused on tea’s neuroprotective effects on AD progression with the classical AD model organism Caenorhabditis elegans strain CL4176. Pretreatment with Zijuan Pu’er tea (ZJPT), Xihu Longjing Tea (XHLT), Jasmine Tea (JT) and Japanese Motcha Tea (JM) before Aβ production led to a significant reduction in the paralysis rate and numerical decrease of Aβ production of the CL4176 strain. Gene expression analysis revealed changes across three functional categories, with genes involved in γ-secretase activity, APP interactors, and tau-related processes. Thus, this study demonstrated tea consumption prior to Aβ production might prevent the onset of AD, probably by regulations of γ-secretase activity, APP interactors, and tau-related processes.