DNA frameworks equipped with high-affinity multivalent aptamers for the reliable and amplified detection of a specific membrane protein
A tetrahedral DNA framework-based fluorescent probe is programmed with multivalent aptamers for the precise targeting of membrane nucleolin and an initiator strand to trigger a hybridization chain reaction. Benefiting from multivalent aptamer targeting and HCR signal amplification, this probe demonstrates minimal endocytosis, enabling the reliable and amplified detection of a membrane protein biomarker.
Authors
- Lianhui Wang (ORCID: https://orcid.org/0000-0001-9030-9172)
- Jie Chao (ORCID: https://orcid.org/0000-0003-1030-9944)
- Mingzhi Zhu (ORCID: https://orcid.org/0000-0003-2694-6278)
- Ziyi Zhou (ORCID: https://orcid.org/0000-0003-0220-8094)
- Qin Fan (ORCID: https://orcid.org/0000-0002-6018-0889)
- Zhimei He (ORCID: https://orcid.org/0000-0002-8509-0142)
- Jianyong Wang (ORCID: https://orcid.org/0000-0003-4695-4806)
- Wenjie Xiang
- Longfei Lai
Institutions
- Nanjing University of Posts and Telecommunications (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04334d
- Citations
- 1
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.81