Hyssopus cuspidatus Boriss Volatile Extract (SXC): A Dual-Action Antioxidant and Antifungal Agent Targeting Candida albicans Pathogenicity and Vulvovaginal Candidiasis via Host Oxidative Stress Modulation and Fungal Metabolic Reprogramming
SXC shows promise as a broad-spectrum natural antimicrobial against fungal pathogens. It inhibited <i>C. albicans</i> hyphal growth, adhesion, biofilm formation, and invasion in vitro, while reducing oxidative and preserving vaginal mucosal integrity in vivo. By disrupting fungal metabolic pathways and modulating host immune responses, SXC offers a novel approach to treating recurrent, drug-resistant VVC.
Authors
- Yanxing Han (ORCID: https://orcid.org/0000-0003-0073-4357)
- Jian‐Dong Jiang
- Cai Tie (ORCID: https://orcid.org/0000-0003-1541-6407)
- Lulu Wang (ORCID: https://orcid.org/0000-0001-7507-4141)
- Yuan Lin (ORCID: https://orcid.org/0000-0001-5449-3435)
- Mingxuan Zhang (ORCID: https://orcid.org/0000-0003-3324-6675)
- Yun-Dan Guo
- Tianle Gao (ORCID: https://orcid.org/0009-0007-4864-0321)
- Q Yu (ORCID: https://orcid.org/0009-0009-1863-438X)
Institutions
- China Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China University of Mining and Technology (CN)
Publication Details
- Journal
- Antioxidants
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3390/antiox14091046
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Natural Science Foundation of China