Melatonin-induced ferroptosis in pancreatic cancer cells by stimulating endoplasmic reticulum stress and inhibiting alanine-serine-cysteine transporter 2-driven glutamine metabolism
Melatonin induces ferroptosis in pancreatic cancer cells by activating transcription factor 4-dependent ER stress and inhibiting glutamine metabolism, promotes apoptosis in pancreatic cancer cells, and inhibits autophagy, leading to synergistic anticancer effects.
Authors
- Qian Zhao (ORCID: https://orcid.org/0000-0001-8757-5680)
- Le Kang (ORCID: https://orcid.org/0000-0003-4262-2329)
- Hong Wu (ORCID: https://orcid.org/0000-0002-0839-1523)
- Qunying Yang (ORCID: https://orcid.org/0000-0002-4196-440X)
- Hui Zhang (ORCID: https://orcid.org/0000-0003-2210-5674)
- Xiangyin Lv
- Hong Zhao (ORCID: https://orcid.org/0000-0001-8571-6419)
Institutions
- Wenzhou Medical University (CN)
- Dongyang People's Hospital (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3748/wjg.v31.i32.108654
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00