Exploration of gray matter alterations and cognitive function impairment in adolescents with first-episode non-suicidal self-injury and the associations with self-injury characteristics
The cognitive functions of the NSSI group are poorer than those of the HC group. Compared with the HC group, the NSSI group had decreased GMV in the left putamen and left nucleus accumbens and an increased GMV in the left rostral anterior cingulate cortex. In the NSSI group, the self-injury characteristics and poorer cognitive function are associated with abnormal alternations in GMV, and the poorer cognitive functions are also associated with the self-injury characteristics. The mediation analysis showed that the volume of the left rostral anterior cingulate cortex played a partial mediating role in the relationship between NSSI behavior and cognitive decline.
Authors
- Kwong‐Kum Liao (ORCID: https://orcid.org/0000-0003-4920-0639)
- Yuwei Chen (ORCID: https://orcid.org/0009-0006-2547-5135)
- Sen Peng (ORCID: https://orcid.org/0000-0002-3337-3749)
- Nian Liu (ORCID: https://orcid.org/0000-0001-5482-7626)
- Xinyue Chen (ORCID: https://orcid.org/0000-0003-3212-2398)
- Xianfu Li (ORCID: https://orcid.org/0000-0002-1258-1573)
- Rui Yu (ORCID: https://orcid.org/0000-0002-3634-8004)
Institutions
- North Sichuan Medical University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Science and Technology Department of Sichuan Province (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-08-26
- DOI
- https://doi.org/10.7717/peerj.19914
- Primary Topic
- Suicide and Self-Harm Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00