Synthesis of Telechelic‐Type Polypeptides Functionalized with Aromatic Units and the Characterization of Their Structures and Thermal Properties
To enhance their physical and thermal properties, telechelic polypeptides with extended peptide chains from aromatic diamines were synthesized via the chemoenzymatic polymerization of diamine-type initiators and amino acid esters. With the introduction of meta-substituted aromatic diamines, atomic force microscopy (AFM) revealed the formation of large aggregates in telechelic polyalanine (TPA), which was attributed to π‒π stacking interactions between aromatic rings, as well as short fibrous aggregates with branched structures. The introduction of rigid aromatic rings also improved the thermal stability of the polypeptides.
Authors
- Yusuke Ueno (ORCID: https://orcid.org/0000-0001-5761-292X)
- Keiji Numata (ORCID: https://orcid.org/0000-0003-2199-7420)
- Hiroyasu Masunaga (ORCID: https://orcid.org/0000-0002-0939-2114)
- Kousuke Tsuchiya (ORCID: https://orcid.org/0000-0003-2364-8275)
Institutions
- Tokyo University of Technology (JP)
- Kyoto University (JP)
- RIKEN Center for Sustainable Resource Science (JP)
- Japan Synchrotron Radiation Research Institute (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Macromolecular Rapid Communications
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1002/marc.202500499
- Primary Topic
- Silk-based biomaterials and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Asahi Glass Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Precursory Research for Embryonic Science and Technology
- Co-creation place formation support program
- JST-Mirai Program