Methamphetamine-Induced Loss of Syndecan-1 and Retinal Endothelial Integrity via the TAAR-1/MMP-9 Pathway
Our findings suggest that METH induces loss of syndecan-1 and retinal vascular integrity by promoting TAAR-1-mediated MMP-9 upregulation. Targeting the TAAR-1/MMP-9 axis may offer a promising therapeutic strategy for preventing METH-induced microvascular damage in the retina.
Authors
- Tuanzhu Ha (ORCID: https://orcid.org/0000-0001-8244-4585)
- Wendy Leskova
- Norman R. Harris (ORCID: https://orcid.org/0000-0001-7334-8153)
- Min‐Sup Lee (ORCID: https://orcid.org/0000-0002-7188-5366)
- Ivan A. Alvarez (ORCID: https://orcid.org/0009-0008-5656-0169)
- Changwon Park (ORCID: https://orcid.org/0000-0003-0635-921X)
Institutions
- Louisiana State University (US)
- University of Kentucky (US)
- Louisiana State University Health Sciences Center Shreveport (US)
Publication Details
- Journal
- Pathophysiology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3390/pathophysiology32030041
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Louisiana State University