Photocatalyzed C(sp<sup>3</sup>)–N Bond Activation of Isonitriles for Mizoroki–Heck Cross-Coupling with Vinyl Arenes
We report a Mizoroki-Heck reaction enabled by the visible-light-induced Pd-catalyzed C-N bond cleavage of isonitriles. Through a one-carbon activation of amines, we eliminated the need for atom-inefficient activating groups, thereby allowing isonitriles to serve as alkyl radical precursors. The utility of this protocol was demonstrated with a variety of (hetero)aromatic-containing isonitriles and differentially substituted vinyl arenes. This transformation expands the range of cross-coupling reactions that amine precursors can undergo.
Authors
- Alexander W. Schuppe (ORCID: https://orcid.org/0000-0001-6002-9110)
- Seunho Jung (ORCID: https://orcid.org/0000-0002-0801-9342)
- Andrew Wood (ORCID: https://orcid.org/0000-0001-7536-6398)
- N. Mizuno
Institutions
- Vanderbilt University (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1021/acs.orglett.5c02954
- Citations
- 3
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Vanderbilt University
- Chiba University
- National Institute of General Medical Sciences