Trace amine-associated receptor 1 (TAAR1) activation reduced mania-relevant hyperexploration and risky decision-making in dopamine transporter knockdown mice
These findings support the potential for TAAR1 agonists as novel treatments for hyperactivity and risky decision-making in BD, and suggest an inverted <i>U</i>-shaped relationship between dopamine tone and decision-making optimization.
Authors
- Tarannum Yumi Munir
- Jared W. Young (ORCID: https://orcid.org/0000-0003-3732-5776)
- Benjamin Z. Roberts (ORCID: https://orcid.org/0000-0003-2209-3159)
Institutions
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- Mental Illness Research, Education and Clinical Centers (US)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1177/02698811251364394
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Brain and Behavior Research Foundation
- National Institute on Drug Abuse