ST2+ effector memory helper T cells are responsible for long-term asthma exacerbation leading to female-predominant airway inflammation
Our findings suggest that the contribution of memory T cells to asthmatic inflammation varies depending on sex, and female predominance is attributable to an increased number of ST2<sup>+</sup>CD4<sup>+</sup> circulating memory T cells.
Authors
- Kaoru Toshima
- Chiaki Masuda-Suzuki
- Kaori Kawakami (ORCID: https://orcid.org/0000-0003-3694-8322)
- Tasuku Kawano (ORCID: https://orcid.org/0000-0001-6978-6361)
- Fumi Shishido
- Tomomitsu Miyasaka (ORCID: https://orcid.org/0000-0001-7218-6981)
- Yutaka Nakamura (ORCID: https://orcid.org/0000-0001-8717-1475)
- Kaori Dobashi-Okuyama
- Hiroyuki Tanaka (ORCID: https://orcid.org/0000-0003-3777-6112)
- Tomoko Takahashi (ORCID: https://orcid.org/0000-0003-4683-6041)
- Masashi Sasaki (ORCID: https://orcid.org/0000-0003-2771-9165)
- Naoko Nagano
- Tomohiro Arikawa
- Motoaki Takayanagi
- Masayuki Seki
- Hideaki Morita
- Isao Ohno
Institutions
- Gifu Pharmaceutical University (JP)
- National Center For Child Health and Development (JP)
- Gifu University (JP)
- Tohoku Medical and Pharmaceutical University (JP)
Publication Details
- Journal
- Allergology International
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1016/j.alit.2025.08.001
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00