Facile access to multi-substituted trifluoromethyl alkenes <i>via</i> dehydroxyfluorination of 3,3-difluoroallyl alcohols
The dehydroxyfluorination of allylic alcohols stands as one of the most direct and effective methods for synthesizing versatile allylic fluorides. However, regioselectivity control in this transformation remains challenging. Herein, we demonstrate a fluorine effect-induced regiospecific dehydroxyfluorination of 3,3-difluoroallyl alcohols using Olah's reagent under mild reaction conditions.
Authors
- Chao Feng (ORCID: https://orcid.org/0000-0003-4494-6845)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-8734-3003)
- Zhiqiang Li (ORCID: https://orcid.org/0000-0002-3283-6385)
- Cheng‐Qiang Wang (ORCID: https://orcid.org/0000-0002-3752-9384)
- Zaixin Wang
Institutions
- Nanjing Tech University (CN)
- Hangzhou Normal University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01233c
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00