Distinct memory CD4 <sup>+</sup> T cell subset tropism of two CCR5-tropic HIV-1 in a rapid progressor
This case report demonstrates that CCR5 HIV-1 variants have distinct memory CD4<sup>+</sup> T cell subset preferences <i>in vivo</i>. Because CD4<sup>+</sup> T cell subset targeting is highly relevant for HIV-1 pathogenesis, understanding the underlying molecular mechanisms may provide deeper insights into HIV-1 therapeutics and functional cure.
Authors
- Sodsai Tovanabutra (ORCID: https://orcid.org/0000-0002-5946-4227)
- Eric Sanders‐Buell (ORCID: https://orcid.org/0000-0002-1694-0529)
- Leilani Francisco (ORCID: https://orcid.org/0000-0002-1074-6418)
- Hongshuo Song
- Manukumar Honnayakanahalli Marichannegowda (ORCID: https://orcid.org/0000-0002-6488-7136)
- Leigh Anne Eller (ORCID: https://orcid.org/0000-0003-2043-1513)
- N L Michael
- Meera Bose (ORCID: https://orcid.org/0000-0003-4151-0958)
- David B. King (ORCID: https://orcid.org/0000-0001-6906-0982)
- Merlin L. Robb (ORCID: https://orcid.org/0000-0003-3949-9649)
- Abdur Rashid (ORCID: https://orcid.org/0000-0002-4539-5320)
- Yasmine Farah
Institutions
- University of Maryland, Baltimore (US)
- Henry M. Jackson Foundation (US)
- University of South Florida (US)
- Global Virus Network (US)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- ASM Case Reports
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1128/asmcr.00101-25
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health