Investigation of the Relationship Between HbA1c Levels and Inflammatory Markers

The purpose of our study is to evaluate the possible complications and treatment process in diabetic patients by examining the relationship between neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), C-reactive protein (CRP), sedimentation and Systemic Immun Inflamation Index (SII). The study included who had HbA1c tests taken from the outpatient and in hospital patients of Aydin Adnan Menderes University Hospital between January-August 2023. The demographic data and HbA1c, NLR, PLR, SII, sedimentation, CRP were recorded. Patients were divided into 3 groups as non-diabetic (HbA1c<6%), prediabetes (6–6.4%) and (≥6.5%) diabetic. The levels of various inflammation markers were compared between different patient groups. A statistically significant relation was identified between HbA1c levels and albumin (p<0.001), CRP (p=0.003), sedimentation (p<0.001), and NLR (p=0.021). Upon examination of the HbA1c groups as discrete categories, namely non-diabetes (<6), prediabetes (6-6.4) and diabetes (>6.5), at the level of non-diabetes and prediabetes a notable relation was observed between albumin (p=0.028), CRP (p=0.013) and sedimentation (p=0.014). Once more, a statistically significant relationship was identified between albumin (p<0.0001), CRP (p=0.013), sedimentation (p<0.0001) and NLR (p=0.020) in the non-diabetic and diabetic groups. No notable relation was identified between the prediabetes and diabetes groups and any of the inflammatory markers under investigation (p>0.05). The findings of our study indicate that in patients with diabetic (>6.5) or non-diabetic (<6) HbA1c, the use of NLR and SII as inexpensive and readily accessible inflammatory markers is a viable proposition.