Continuous adipose-derived stem cell therapy from the neonatal stage effectively reduces Duchenne muscular dystrophy symptoms in rats
Early and sustained MSC administration offers superior structural and functional protection in DMD rats, highlighting the importance of treatment timing in maximizing therapeutic efficacy.
Authors
- Ryo Takagi (ORCID: https://orcid.org/0000-0002-5930-0329)
- Masayuki Yamato (ORCID: https://orcid.org/0000-0002-3146-1024)
- Keitaro Yamanouchi
- Keiko Ishigaki (ORCID: https://orcid.org/0000-0001-8435-7418)
- Yuki Kihara (ORCID: https://orcid.org/0009-0003-9355-5397)
- Satoru Nagata
- Masanari Ikeda
Institutions
- Tokyo Women's Medical University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s13287-025-04594-x
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Tokyo Women's Medical University
- Japan Society for the Promotion of Science