P90 | Prevalence and antimicrobial resistance of germs in a Campania region Internal Medicine ward in 2022

Background: In recent years, antibiotic resistance (AMR, Antimicrobial resistance) increased significantly and made it necessary to evaluate its impact on public health. In Campania the% of resistance to carbapenems, 3rd generation cephalosporins, fluoroquinolones and aminoglycosides are all higher than those detected by the EARS-Net network in Italy and Europe; the marked differences concern the% resistance of invasive strains of K. pneumoniae, 3rd generation cephalosporins, fluoroquinolones and carbapenems. We evaluated the prevalence of the main pathogenic germs in our Medicine ward in the year 2022 and any AMR. Materials and Methods: In 2022, 788 culture tests were performed on 471 hospitalized patients. We observed a prevalence for G-: 23.6% E. coli, 12.5% Klebsiella pn, 17.7% Acinetobacter, 17.7% Pseudomonas ae; for G+: 31% Ent. faecium, 24.6% Ent. Faecalis, 24.6% Staph au. These data are different from those shown in the 2019 report on AMR in public structures of the Campania healthcare system; in fact in our ward we detected a prevalence of Acinetobacter and Pseudomonas tripled if compared to the 2019 Campania region data. For AMR in G- this is 87% for cefipime and aztreonam, 40% ciprofloxacin, 35% ceftazidime, 100% tygecycline and 20% piperacillin/tazobactam; for enterococci it’s 55% for amoxicillinia/clav, ampicillin+sulb and imipenem and 57% cipro-levofloxacin, similar to the other G+; while for fungi only fluconazole has an AMR of 25%. Conclusions: These data demonstrate how important it is to know the germs (and the relative AMR) of your own ward so to improve good clinical practices.