Extracellular vesicles derived from clonal mesenchymal stromal cells preconditioned by indirect hypoxia modulate immune responses in diabetic mice more effectively than directly preconditioned vesicles
Our results showed the effectiveness of direct/indirect hypoxia preconditioning for cMSCs to modulate immune responses in the MLD/STZ-induced mice model. This study demonstrated that the immunomodulatory potential of iH-MSC-EVs is significantly greater than that of dH-MSC-EVs and their source cells. Our results suggest iH-MSC-EVs, could be a potential option for modulating the immune response in T1D.
Authors
- Nader Fallah (ORCID: https://orcid.org/0000-0002-7746-4773)
- Ensiyeh Hajizadeh‐Saffar
- Saeed Mohammadi (ORCID: https://orcid.org/0000-0002-8759-1194)
- Saeed Yakhkeshi
- Seyedeh‐Nafiseh Hassani (ORCID: https://orcid.org/0000-0001-5047-8406)
- Samira Vesali (ORCID: https://orcid.org/0000-0003-0005-8045)
- Mahnaz Babaahmadi (ORCID: https://orcid.org/0000-0003-2879-3199)
- Maryam Hezavehei (ORCID: https://orcid.org/0000-0003-1460-1862)
- Mojgan Barati (ORCID: https://orcid.org/0000-0002-6969-4755)
- Faezeh Shekari (ORCID: https://orcid.org/0000-0001-6026-5412)
- Mehdi Soleymani-Goloujeh (ORCID: https://orcid.org/0000-0002-6478-3951)
- Hossein Baharvand (ORCID: https://orcid.org/0000-0001-6528-3687)
- Mahmoud Alipour Choshali
- Masoumeh Azimi
- Nima Makvnd Gholipour
Institutions
- University of Science and Culture (IR)
- Royan Institute (IR)
- Academic Center for Education, Culture and Research (IR)
- Cegep de Saint Hyacinthe (CA)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s13287-025-04568-z
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Science Foundation
- Iran National Science Foundation
- Royan Institute
- Academic Center for Education, Culture and Research
- Iranian Council of Stem Cell Research and Technology