Chromatin remodeling and H3K4me3 depletion regulate germline specification from pluripotency
The comprehensive analysis of gene expression and chromatin regulation patterns during germ/soma segregation reveals that chromatin reprogramming mechanisms play crucial roles in controlling germline specification. This research also provides new epigenetic strategies to enhance the production of germ cells.
Authors
- Ruimin Ren
- Yinlong Liao
- Zhelun Peng (ORCID: https://orcid.org/0000-0002-4468-1528)
- Yao Hua
- Sheng Wang (ORCID: https://orcid.org/0000-0002-1809-3116)
- Heng Wang (ORCID: https://orcid.org/0000-0002-1727-9226)
- Xiaochen Huang (ORCID: https://orcid.org/0000-0002-0261-8192)
- Lu Meng
- Guiyu Zhu (ORCID: https://orcid.org/0009-0007-4347-7668)
Institutions
- Second Military Medical University (CN)
- Shandong Agricultural University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s13287-025-04584-z
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00