Conditional immortalization of mesenchymal stem cells and their extracellular vesicles therapy for interstitial cystitis/bladder pain syndrome
In summary, this approach produced a reliable source of functional MSCs and EVs, with iMSC-EVs demonstrating robust immunomodulatory properties and promoting tissue healing in IC/BPS. This method represents a promising alternative to pMSCs for IC/BPS therapy.
Authors
- Guolong Liao (ORCID: https://orcid.org/0000-0002-6421-3449)
- Jianhua Yang (ORCID: https://orcid.org/0000-0002-6873-7653)
- Canling Long (ORCID: https://orcid.org/0009-0005-2661-2405)
- Rui Guo (ORCID: https://orcid.org/0000-0002-8234-9817)
- S Wang
- Jia Liu (ORCID: https://orcid.org/0000-0003-0909-7710)
- Ruijuan Han
Institutions
- Sun Yat-sen University (CN)
- Longgang Central Hospital (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s13287-025-04615-9
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Provincial People's Hospital
- Shenzhen Science and Technology Innovation Program