Structure-function relationship of S protein cleavage in cowpea mosaic virus intratumoral immunotherapy
Translational studies are underway for cowpea mosaic virus (CPMV) as a candidate for intratumoral immunotherapy. To further strengthen the argument for translation, here we demonstrate that a structural deviation in CPMV's small (S) coat protein does not negatively impact its antitumor efficacy, immune cell uptake, or cytokine profile.
Authors
- Nicole F. Steinmetz (ORCID: https://orcid.org/0000-0002-0130-0481)
- Marina A. Dobrovolskaia (ORCID: https://orcid.org/0000-0002-4233-9227)
- Andrea Simms (ORCID: https://orcid.org/0000-0002-3104-0588)
- Jessica Fernanda Affonso de Oliveira (ORCID: https://orcid.org/0000-0002-5474-2355)
- Edward Cedrone
- Narek Minasov
Institutions
- University of California San Diego (US)
- Frederick National Laboratory for Cancer Research (US)
Publication Details
- Journal
- Biomaterials Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5bm00969c
- Primary Topic
- Plant Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health