TIM-3 and γδ T cells: new players in breast cancer dissemination
γδ T cells, a heterogeneous lymphocyte subset operating at the interface between innate and adaptive immunity, mediate ambivalent and context-dependent effects in oncological settings. Recent work by Rozalén et al, (2025) demonstrates that IL-17-secreting γδ T cells favor the outgrowth of TIM-3+ triple-negative breast cancer metastases by establishing local immunosuppression.
Authors
- David L. Wiest (ORCID: https://orcid.org/0000-0002-0792-3188)
- Claudia Galassi
- Lorenzo Galluzzi (ORCID: https://orcid.org/0000-0003-2257-8500)
Institutions
- Fox Chase Cancer Center (US)
- Cornell University (US)
- Weill Cornell Medical College in Qatar (QA)
Publication Details
- Journal
- The EMBO Journal
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1038/s44318-025-00550-w
- Citations
- 1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.80