Effects of Treadmill Exercise on Retinal Vascular Morphology, Function, and Circulating Immune Factors in a Mouse Model of Retinal Degeneration
Treadmill exercise maintained retinal vascular morphology and function, altered endothelial gene expression, and is associated with a specific circulating immune response profile in the LIRD mouse model. These data support exercise as an effective intervention for maintaining retinal vascular integrity in a model of RD.
Authors
- Machelle T. Pardue (ORCID: https://orcid.org/0000-0001-8738-6839)
- Katie L. Bales
- Jeffrey H. Boatright (ORCID: https://orcid.org/0000-0001-5875-492X)
- H Haupt
- John M. Nickerson (ORCID: https://orcid.org/0000-0003-2419-9897)
Institutions
- Georgia Institute of Technology (US)
- Emory University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Atlanta VA Health Care System (US)
- Atlanta VA Medical Center (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1167/iovs.66.11.65
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00