Hyperglycemia-Reduced Platelet-Derived Growth Factor–BB Expression Impairs Corneal Wound Healing in Diabetic Mice
Hyperglycemia suppresses PDGF-BB expression, impairing corneal epithelial wound healing and nerve regeneration by inhibiting ERK1/2 and AKT signaling. PDGF-BB may represent a potential therapeutic strategy for diabetic keratopathy.
Authors
- Wei Zhu (ORCID: https://orcid.org/0000-0002-5237-1992)
- Qingjun Zhou (ORCID: https://orcid.org/0000-0002-7770-9275)
- Huabo Chen (ORCID: https://orcid.org/0000-0002-1276-9947)
- Ya Li (ORCID: https://orcid.org/0000-0002-3351-7909)
- Yangyang Zhang (ORCID: https://orcid.org/0000-0002-2055-6327)
- Zhenzhen Zhang (ORCID: https://orcid.org/0000-0002-5151-3602)
- Rui Wang (ORCID: https://orcid.org/0000-0002-5901-1332)
- Yanling Liu (ORCID: https://orcid.org/0000-0002-2027-6464)
- Lixin Xie (ORCID: https://orcid.org/0000-0003-2747-3361)
- Qi Xia (ORCID: https://orcid.org/0000-0003-0232-7624)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1167/iovs.66.11.61
- Citations
- 3
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.08