Hypercapnia promotes maladaptive airway and vascular remodeling in mice

CO2 isn't just a gas-it can remodel lungs and worsen COPD, but may be reversible with CO2-lowering therapies.

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Publication Details

Journal
Journal of Clinical Investigation
Published
2025-08-26
DOI
https://doi.org/10.1172/jci196928
Primary Topic
Neuroscience of respiration and sleep
Type
article
Field-Weighted Citation Impact
0.00

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Hypercapnia promotes maladaptive airway and vascular remodeling in mice

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Hypercapnia promotes maladaptive airway and vascular remodeling in mice

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article en

Abstract

CO2 isn't just a gas-it can remodel lungs and worsen COPD, but may be reversible with CO2-lowering therapies.

Journal of Clinical InvestigationVol. 135(21)
Northwestern University (US), Thoracic Surgery Foundation (US), Northwestern University (PH), Jesse Brown VA Medical Center (US), Northwestern Medicine (US), Pulmonary and Critical Care Associates (US), Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Centre for Advanced Microscopy
U.S. Department of Veterans Affairs, National Institutes of Health
Zero hunger
Openalex Percentile: Top 76%
Neuroscience of respiration and sleep
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