Hypercapnia promotes maladaptive airway and vascular remodeling in mice
CO2 isn't just a gas-it can remodel lungs and worsen COPD, but may be reversible with CO2-lowering therapies.
Authors
- Estefani Diaz (ORCID: https://orcid.org/0000-0003-4146-0276)
- Masahiko Shigemura (ORCID: https://orcid.org/0000-0001-7767-6584)
- Felix Nunez-Santana (ORCID: https://orcid.org/0000-0002-2857-1441)
- Sajjad Mohsin (ORCID: https://orcid.org/0000-0001-7945-2509)
- Suchitra Swaminathan (ORCID: https://orcid.org/0000-0002-8292-122X)
- Chitaru Kurihara (ORCID: https://orcid.org/0000-0003-3536-4675)
- G. R. Scott Budinger (ORCID: https://orcid.org/0000-0002-3114-5208)
- Lynn C. Welch (ORCID: https://orcid.org/0000-0003-1666-3696)
- Ankit Bharat (ORCID: https://orcid.org/0000-0002-1248-0457)
- Yuliana V. Sokolenko (ORCID: https://orcid.org/0000-0001-9872-0484)
- Emilia Lecuona (ORCID: https://orcid.org/0000-0003-4387-1386)
- David Kirchenbüechler
- S. Marina Casalino‐Matsuda (ORCID: https://orcid.org/0000-0002-7566-4560)
- Radmila Nafikova (ORCID: https://orcid.org/0000-0003-2850-9178)
- Rizaldy P. Scott (ORCID: https://orcid.org/0000-0002-0288-8862)
- Peter H. S. Sporn (ORCID: https://orcid.org/0000-0002-1006-9437)
- Jacob I. Sznajder (ORCID: https://orcid.org/0000-0002-2089-4764)
- Fei Chen (ORCID: https://orcid.org/0000-0002-6988-492X)
- Zhan Yu (ORCID: https://orcid.org/0000-0003-4389-0384)
Institutions
- Northwestern University (US)
- Thoracic Surgery Foundation (US)
- Northwestern University (PH)
- Jesse Brown VA Medical Center (US)
- Northwestern Medicine (US)
- Pulmonary and Critical Care Associates (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Centre for Advanced Microscopy
Publication Details
- Journal
- Journal of Clinical Investigation
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1172/jci196928
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health