Protective Effect of Low 2-O, 3-O Desulfated Heparin (ODSH) Against LPS-Induced Acute Lung Injury in Mice
ODSH mitigates LPS-induced ALI by reducing vascular permeability, neutrophilic inflammation, and pro-inflammatory signaling while enhancing IL-10 expression. These findings suggest ODSH may offer a novel therapeutic approach for treating ALI.
Authors
- Joaquin U. Gonzales (ORCID: https://orcid.org/0000-0002-6629-8511)
- Nagavedi S. Umapathy
- Rudolf Lucas (ORCID: https://orcid.org/0000-0003-3805-8868)
- Rahul Patil (ORCID: https://orcid.org/0000-0003-2447-2355)
- Alexander D. Verin (ORCID: https://orcid.org/0000-0003-0627-7185)
- Thomas P. Kennedy (ORCID: https://orcid.org/0000-0002-8862-2765)
Institutions
- Augusta University (US)
- GlycoMira Therapeutics (United States) (US)
- Wake Forest University (US)
- Vertex Pharmaceuticals (United States) (US)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3390/biom15091232
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Historical Association
- National Heart, Lung, and Blood Institute