The STUB1-TPIT axis regulates the secretion of adrenocorticotrophic hormone in cushing disease
STUB1 is a promising therapeutic target for CD and drugs targeting the STUB1-TPIT complex may provide a potential treatment approach.
Authors
- Shaojian Lin (ORCID: https://orcid.org/0000-0002-7555-0520)
- Jian‐Gong Ma (ORCID: https://orcid.org/0000-0001-7407-5521)
- Xue Li (ORCID: https://orcid.org/0000-0002-7501-4445)
- Tao Zhang (ORCID: https://orcid.org/0000-0002-8157-7674)
- Fang Liu (ORCID: https://orcid.org/0000-0001-5263-3035)
- Desheng Chen (ORCID: https://orcid.org/0000-0003-0201-6025)
- Yanting Liu (ORCID: https://orcid.org/0000-0002-7306-4502)
- Zhe Wu (ORCID: https://orcid.org/0000-0002-1611-8228)
- Ning Huang (ORCID: https://orcid.org/0009-0008-5160-4222)
- Xiaobin Wang
Institutions
- Wenzhou Medical University (CN)
- Ruijin Hospital (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- State Key Laboratory of Oncogene and Related Genes (CN)
- First Affiliated Hospital of Henan University (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12967-025-06960-y
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Henan University
- Shanghai Jiao Tong University
- Ruijin Hospital