Airway microbiota and immunity associated with chronic obstructive pulmonary disease severity
This study identifies microbial and immune signatures associated with COPD severity, providing mechanistic insights into its pathophysiology. The findings may inform precision medicine strategies by targeting airway dysbiosis and immune dysregulation. While causal relationships could not be established in this cross-sectional study, the findings provide a foundation for future mechanistic investigations using advanced in vitro and in vivo models.
Authors
- Juhua Yang (ORCID: https://orcid.org/0009-0006-6345-9910)
- Baoqing Sun (ORCID: https://orcid.org/0000-0002-1671-0723)
- Zhiwei Lin (ORCID: https://orcid.org/0000-0002-9772-486X)
- Ke Zhang (ORCID: https://orcid.org/0000-0002-3546-9015)
- Bin Yang (ORCID: https://orcid.org/0000-0002-6604-5565)
- Huifang Liu (ORCID: https://orcid.org/0000-0003-1545-5828)
- Bo Xiang (ORCID: https://orcid.org/0000-0002-5388-9101)
- Peiren Tang
- Yueting Jiang
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Vision Medicals (China) (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12967-025-06986-2
- Citations
- 10
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 15.18
Funders
- Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases