Diminished Estrogen Induced Mitochondrial Protection and Immunosuppressive Microenvironment in Gastric Cancer with Depression
This work identified the estrogen/NOTCH3 signaling as a key link between depression and gastric cancer development, offering promising therapeutic strategies to improve outcomes for patients suffering from psychological disorders.
Authors
- Yixin Liu (ORCID: https://orcid.org/0000-0002-1627-7720)
- Pearlly S. Yan (ORCID: https://orcid.org/0000-0003-1965-4920)
- Yongchang Wei (ORCID: https://orcid.org/0000-0001-7205-4663)
- Sachiyo Nomura (ORCID: https://orcid.org/0000-0003-4293-6205)
- Tianhe Huang (ORCID: https://orcid.org/0000-0002-2737-4016)
- Sheng Tian
- Yujia Tan (ORCID: https://orcid.org/0000-0003-3607-9446)
- Huiying Zhu
- Pan Liu (ORCID: https://orcid.org/0000-0002-6999-6550)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- The University of Tokyo (JP)
Publication Details
- Journal
- Cancers
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3390/cancers17172789
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- CIEE Ping Foundation
- National Natural Science Foundation of China
- Wuhan University
- Zhongnan Hospital of Wuhan University