The Novel Immunocompetent Eµ-SOX11CCND1 Mouse Model Phenotypically and Molecularly Resembles Human Mantle Cell Lymphoma
The Eµ-SOX11CCND1 mouse represents a robust and biologically relevant model that faithfully recapitulates human MCL. Its immunocompetent nature and adoptive transfer capability make it a valuable model for studying disease mechanisms and evaluating novel therapeutic approaches for patients with MCL.
Authors
- Cem Meydan (ORCID: https://orcid.org/0000-0002-0663-6216)
- Robert A. Baiocchi (ORCID: https://orcid.org/0000-0002-1619-4853)
- Peggy Scherle (ORCID: https://orcid.org/0000-0003-0783-6815)
- Paul Collier (ORCID: https://orcid.org/0009-0005-6198-5987)
- Rosa Lapalombella (ORCID: https://orcid.org/0000-0001-6916-9400)
- Donna Edwards (ORCID: https://orcid.org/0009-0006-6749-0413)
- Robert B. Faryabi (ORCID: https://orcid.org/0000-0002-7931-2175)
- Samir Sunil Parekh (ORCID: https://orcid.org/0000-0001-9694-8469)
- Betsy Pray (ORCID: https://orcid.org/0000-0001-8629-3454)
- Hedieh Jafari (ORCID: https://orcid.org/0000-0001-9129-2720)
- Rosario Distefano (ORCID: https://orcid.org/0000-0001-7241-7751)
- Wing Keung Chan (ORCID: https://orcid.org/0000-0002-5257-1521)
- Mackenzie Long (ORCID: https://orcid.org/0000-0001-6387-4440)
- Violetta V. Leshchenko (ORCID: https://orcid.org/0000-0003-2989-0601)
- Walter Hanel (ORCID: https://orcid.org/0000-0001-8982-6877)
- Kris Vaddi (ORCID: https://orcid.org/0009-0009-8581-6511)
- JoBeth Helmig-Mason (ORCID: https://orcid.org/0009-0009-5872-5171)
- Satishkumar Singh (ORCID: https://orcid.org/0000-0001-9957-9566)
- Lapo Alinari (ORCID: https://orcid.org/0000-0002-8870-4162)
- Alessandro La Ferlita (ORCID: https://orcid.org/0000-0002-3680-3177)
- Lalit Sehgal (ORCID: https://orcid.org/0000-0002-1151-5427)
- Shelby Sloan (ORCID: https://orcid.org/0000-0001-7366-9184)
- Kara N. Corps (ORCID: https://orcid.org/0000-0002-5584-6738)
- Christopher E. Mason (ORCID: https://orcid.org/0000-0002-1850-1642)
- Ian Hout (ORCID: https://orcid.org/0009-0002-2243-5534)
- Ravi Prakash Shukla (ORCID: https://orcid.org/0000-0001-7492-5848)
- Sidorela Reci (ORCID: https://orcid.org/0009-0006-3923-5132)
- Sydney Leon (ORCID: https://orcid.org/0009-0008-3937-8736)
Institutions
- University of Georgia (US)
- German Cancer Research Center (DE)
- Columbus State University (US)
- Cornell University (US)
- Wilmington University (US)
- Heidelberg University (DE)
- The Ohio State University Wexner Medical Center (US)
- Lander Institute (IL)
- Tisch Hospital (US)
- Weill Cornell Medicine (US)
- The Ohio State University (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0534
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00