Inflammatory and Mucociliary Dysfunction-Based Endotypes Across the Spectrum of Chronic Airway Diseases
Our results indicate that airway diseases have heterogeneous mucus properties. Patients were shown to cluster according to inflammatory endotype rather than disease label. Assessment based on disease labels may be aided by endotyping using inflammatory and mucociliary clearance biomarkers.
Authors
- Mathieu Bottier (ORCID: https://orcid.org/0000-0002-3148-6491)
- Jeffrey Huang (ORCID: https://orcid.org/0000-0001-9982-2298)
- Lídia Perea (ORCID: https://orcid.org/0000-0002-1624-0012)
- Simon Finch
- Daniela Alferes (ORCID: https://orcid.org/0000-0002-5125-1657)
- Jamie Stobo
- Erin Cant
- James Duncan Chalmers (ORCID: https://orcid.org/0000-0001-5514-7868)
- Amelia Shoemark (ORCID: https://orcid.org/0000-0001-7360-6060)
- Morven Shuttleworth
- Merete Bridget Long
- Hollian Richarson
Institutions
- Ninewells Hospital (GB)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
Publication Details
- Journal
- CHEST Journal
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1016/j.chest.2025.07.4087
- Citations
- 5
- Primary Topic
- Respiratory and Cough-Related Research
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- Novartis